Lena and James are attacked by Reign at Lena’s place. Lena uses Kryptonite against Reign which forces Reign to retreat.

Lena is questioned at the DEO and reveals that she contained Reign using the last of Lex’s Kryptonite. At the Fortress of Sanctuary, the Worldkillers work to bring about a total eclipse.

The DEO investigates the rash of dead animals; it spreads to humans, as people develop flu-like symptoms with a large scratch on their wrists. Imra believes this is the work of Pestilence, the third Worldkiller.

Lena brings Sam out of sedation and tells her that her blood tests are normal, but further analysis shows Sam undergoes a metamorphosis at the cellular level when she becomes Reign

In Supergirl S03E14, Supergirl’s friend, Winn, have to face with his death father and co-operate with his estranged mother to fight back to Toyman.

Supergirl S03E13, Lena is poisoned with cyanide in her coffee by an unknown hitman. James pursues the hitman, who is eventually shot down by an unseen sniper.

Kara fights an amazing metahuman burglar called Psi, who can bring out her casualties’ most profound feelings of dread, compelling Kara to battle with her recollections of Krypton’s demolition and her blame over Mon-El.