Trapped in the white room, Clarke tries to make sense of her surroundings. The Ark survivors face moral and physical dilemmas. An old enemy returns.
As the conflict escalates, Clarke pleads with Bellamy to do the right thing. Octavia makes a difficult choice. Raven and Jasper work against time.
Clarke and Finn are confronted by a new enemy, Bellamy makes a heroic move to save Jasper, while those on the Ark face the inevitable.
When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart.
Dawn and Alex await a legal decision on whether to resuscitate Charlie. Meanwhile, they must work together on a heart transplant surgery.
Joel performs surgery on Karn , whose self-implanted horns have become infected. The medical team decides to remove the horns, against Karn’s vehement wishe.
Clarke and Finn lead a hunt for food, Raven makes Bellamy an offer he can’t refuse, and Kane risks his life and reunites with Jaha and Abby.