Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.
When Alex’s brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex.
Lena is questioned at the DEO and reveals that she contained Reign using the last of Lex’s Kryptonite. At the Fortress of Sanctuary, the Worldkillers work to bring about a total eclipse.
The DEO investigates the rash of dead animals; it spreads to humans, as people develop flu-like symptoms with a large scratch on their wrists. Imra believes this is the work of Pestilence, the third Worldkiller.
