Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.

When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart.

When the life of one of the doctors at Hope Zion Hospital is at risk, Alex has to put her personal and professional issues aside. Charlie has to deal with the ghost of a ballerina.