The DEO investigates the rash of dead animals; it spreads to humans, as people develop flu-like symptoms with a large scratch on their wrists. Imra believes this is the work of Pestilence, the third Worldkiller.

Lena is questioned at the DEO and reveals that she contained Reign using the last of Lex’s Kryptonite. At the Fortress of Sanctuary, the Worldkillers work to bring about a total eclipse.

Lena and James are attacked by Reign at Lena’s place. Lena uses Kryptonite against Reign which forces Reign to retreat.

Kara and James discuss Lena’s mistrust of Supergirl and keeping secret identities. Tonya, a Coville follower, brings Coville’s personal journal for James to give to Supergirl.

Kara and Mon-El reach the meteor and discover there is a city on it. They are attacked by caretaker droids, but use disguises to blend in while traveling through the city towards the rock.

Kara and Mon-El fight Reign as Lena creates an antidote from the Harun-El. Once injected, Reign separates from Sam and disintegrates.

Coville, Selena and the other Kryptonians begin a ritual at the Fortress of Sanctuary to summon Reign back to Earth.