When a highly decorated doctor named Richard Nelson is poisoned with a fatal dose of radiation, Reese and Finch have just 24 hours to determine the deadly toxin he was given and find the person behind the attack.

Reese monitors Michael Cole’s family where Shaw finds him. Finch calls with a new number, that of Monica Jacobs , a high-ranking employee of a technology company called Rylatech.

The Machine generates the number of watch repairman Lou Mitchell , who is consistently losing large sums of money at a casino. Finch & Reese find out that he and many other elderly gamblers are victims of a drug-money laundering operation headed by the casino’s owner Dario Makris .

After being silent for three days, when the Machine generates numbers of six missing people, Reese, Finch, and Detective Carter realize that they are hunting a serial killer who assumes the identity of his victims.

The machine gives the numbers of Sameen Shaw , a government assassin, and Michael Cole , a computer specialist working for Special Counsel .

Reese and Finch work undercover in a hotel to protect a maid named Mira who escaped the war in Kosovo. Mira, who is hiding her true identity, is being followed by a hit squad. She refuses to cooperate with a reporter investigating a Serbian general’s war crimes.

Reese protects eccentric Internet billionaire Logan Pierce , who is dragging the reputation of his company FriendCzar through the mud with his bad behavior. After several attempts on Pierce’s life, it is revealed that his partner, Justin Ogilvay, has been trying to kill him.