Mike invites Brandon to move in with him, which leads to an argument between Stef and Brandon. Meanwhile, Mariana objects to Jesus dating Lexi; and Callie’s journal assignment sparks memories of a dark secret from her past.
Lena and Mike disagree about whether to punish Brandon. Elsewhere, Jesus tries to cover for Mariana and puts his health at risk in the process, while Callie gets blamed for Mariana’s transgression; and Jesus and Lexi embark on a secret relationship.
Lena meets troubled teen Callie and asks her to temporarily move in with her family in the series premiere of this drama about a lesbian couple heading up a multiethnic family comprised of a biological son and a few adopted children.
Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.