Kara and Mon-El fight Reign as Lena creates an antidote from the Harun-El. Once injected, Reign separates from Sam and disintegrates.
Supergirl S02E22, Both supergirl and superman appear but they need to have their own’s decision. While Supergirl have to battle Rhea to save her city.
Barry Allen and Oliver Queen wake up as wanted criminals hunted by John Deegan as a black suited Superman while Kara is imprisoned at S.T.A.R. Labs, with a rewritten Alex guarding her.
As Kara attempts to adjust to existence without her powers, a seismic tremor hits National City. Winn educates Kara that she needs an ascent of adrenalin in her blood to recover her forces.
Samantha gets ready to go on a trip, leaving Alex to babysit Ruby. The DEO learns that a priestess with knowledge of Reign’s true mission is imprisoned in Fort Rozz
Supergirl S02E12, Alex and Maggie celebrate Valentine’s Day.. Kara refuses to believe her friend is guilty and fights to clear Lena’s arresting.
Coville, Selena and the other Kryptonians begin a ritual at the Fortress of Sanctuary to summon Reign back to Earth.