James gets debilitated with being Guardian when he understands that those he helps fear him. The DEO examines a Phorian lady who utilizes her supernatural forces to cause frenzy.

Samantha wakes up at home with no memory of being in a Kryptonian fortress, but finds she is oddly tired. A mysterious Kryptonian symbol, unknown to Kara, appears throughout National City,

In Supergirl S03E04, Kara investigate someone she think that he or she has mysterious connection to her.

Lena and James are attacked by Reign at Lena’s place. Lena uses Kryptonite against Reign which forces Reign to retreat.

Supergirl S02E17, Aliens attack National City with the intention of collecting a large bounty put out on Supergirl.

The DEO investigates the rash of dead animals; it spreads to humans, as people develop flu-like symptoms with a large scratch on their wrists. Imra believes this is the work of Pestilence, the third Worldkiller.

Supergirl S02E04, An outsider body is found, and the DEO find the killer, who is seized by obscure furnished men. Maggie and Alex track him down to a mystery office facilitating individuals of high political and sparing status keep running by a lady, later distinguished as Veronica Sinclair, otherwise called Roulette.